Human PTGDR2/Apoaequorin Stable Cell Line-CHO

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Creative Bioarray

Business Type:Manufacturer

Country/Region:United States

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8/10

Product Information

  • Certification:CE
  • Brand Name:Creative Bioarray
  • Trademark:Creative Bioarray
  • Place of Origin:Shirley
  • Warranty:1 year

Description

The chemoattractant-homologous receptor expressed on TH2 cells (CRTH2, also known as DP2 and GPR44) serves as a receptor for prostaglandin D2 (PGD2) and has been reported to mediate PGD2-dependent migration of eosinophils. DP2 mediates the pro-inflammatory effects of PGD2 generated in allergic inflammation. 11-Dehydrothromboxane B2 (11-dehydro-TXB2) was found to be a full agonist of the DP2 receptor and hence might cause the receptor activation in cellular contexts where PGD-synthase is not present. Antagonism of the 11-dehydro-TXB2/DP2 axis may be of therapeutic relevance.


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